Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia
نویسندگان
چکیده
منابع مشابه
Cytotoxic Fatty Acid Glycerides from the Seeds of Psoralea Corylifolia
The seeds of Psoralea corylifolia Linn. (Fabaceae) have been used extensively as a remedy for leucoderma and Vitiligo. A number of compounds have been isolated from the seeds like furocoumarins, chalcones, flavonoids, terpenoids etc.. We have reported the cytotoxic and antitumour properties of the hexane extract of the seeds of P.corylifolia. The present investigation reports the identification...
متن کاملStructural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease
Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes a papain-like protease (PLpro) with both deubiquitinating (DUB) and deISGylating activities that are proposed to counteract the post-translational modification of signaling molecules that activate the innate immune response. Here we examine the structural basis for PLpro's ubiquitin chain and interferon stimulated gene 15 (ISG15) ...
متن کاملPhysico-chemical and preliminary phytochemical screening of Psoralea corylifolia
The Psoralea corylifolia is commonly known as babchi or bakuchi, used to cure psoriasis, leprosy, leucoderma, diabetes, indigestion, constipation, cardiac failure, coughs, asthma and osteoporosis. The present study was aimed to investigate the Physico-chemical and preliminary phytochemical screening of Psoralea corylifolia seeds. The extracts of Psoralea corylifolia seeds were prepared using di...
متن کاملInhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3′-digallate (TF3)
SARS-CoV is the causative agent of severe acute respiratory syndrome (SARS). The virally encoded 3C-like protease (3CL(Pro)) has been presumed critical for the viral replication of SARS-CoV in infected host cells. In this study, we screened a natural product library consisting of 720 compounds for inhibitory activity against 3CL(Pro). Two compounds in the library were found to be inhibitive: ta...
متن کاملScreening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds
Psoralea corylifolia L. (Fabaceae) is a widely used medical plant in China. This study was designed to screen and identify bioactive compounds with anticancer activity from the seeds of Psoralea corylifolia L. One volatile fraction (fraction I) and three other fractions (fraction II, III, IV) from methanol extraction of P. corylifolia L. were obtained. Bioactivities of these fractions were eval...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2013
ISSN: 1475-6366,1475-6374
DOI: 10.3109/14756366.2012.753591